UV LED is widely used in disinfection of medical equipment and household products. A Danish team further found that treatment combined with ultraviolet radiation could enhance the effectiveness of bacterial antibiotic eradication. Therefore, light-assisted therapy can reduce the use of antibiotics.
Overuse of antibiotics can lead to bacterial resistance, and at worst to incurable diseases. To prevent this, researchers are trying to find alternative therapies to reduce antibiotic use. With the gradual realization of the bactericidal function of UV-LED, Danish researchers have found that specific wavelength of ultraviolet radiation in vitro can eradicate bacteria in biofilm state more effectively than antibiotics. In addition, according to the team, the combination of UV radiation and antibiotics can better eliminate bacteria, resulting in a new concept, photoassisted antibiotics.
In the study, the team used UV LEDs with wavelengths ranging from 249 to 338 nm for radiation therapy to kill bacteria on biofilms. The results show that the irradiation effect is more remarkable in the range of 292-306 nm, and 296 nm is the best. The results were published in the Science Report on November 5.
By revealing the concept of light-assisted antibiotics, the team hopes to help develop new therapies that combine light sources with antibiotics and enhance the treatment of biofilm infections.